Clinical Pharmacology

Ongoing Projects: 2008- 09

Academic

1. Development of Pharmacovigilance program for adverse drug reactions monitoring in HIV/AIDS and Diabetes.

2. Development of Pharmacovigilance program for adverse drug reactions monitoring in Tuberculosis and Psychiatry

3. Pharmacogenetics of immunosuppressants in renal transplant patients.

4. Use of pharmacokinetic and pharmacodynamic parameters to predict warfarin dosing in patients on long term anti-coagulation.

5. Drug delivery system for safety and efficacy of Anti-Tubercular drugs using Liposomes and Nanoparticles

6. Characterization of Thiopurine S. Methyl Transferase gene polymorphism by genotyping in normal healthy Indian subjects.

7. Evaluation of polymorphism by Cytochrome P450 2D6 by phenotyping and genotyping in normal healthy Maharashtrian volunteers

8. Evaluation of Primaquine Pharmacokinetics in patients with Plasmodium vivax and Plasmodium falciparum malaria.

9. Evaluation of the activity of CYP2A6 in normal healthy adult in western Indian population

Pharmaceutical Industry funded

1. Comparative evaluation of Efficacy and safety of Primaquine Sustained Release tablets Versus Primaquine Conventional tablets in the prevention of relapse of Plasmodium vivax malaria.

2. A Double-blind, Randomized, Placebo Controlled, Trial to Evaluate the Safety and Tolerability of single dose of Advanced Odomos Spray TM in Children

Funding from Government Agencies

1. Phase Ib study with CDR134 – D123 an anti-diabetic compound from marine source in patients with Type-2 diabetes to assess safety, tolerability and efficacy. (Funded by Central Drug Research Institute , Lucknow)

2. Evaluation of the incidence and risk factors for Hyperlactatemia and Lactic acidosis in patients receiving highly active Anti Retroviral Therapy.(HAART) in tertiary referral centres in Mumbai.(NIH Funded)

3. Evaluation of the polymorphism of N-Acetyl Transferase by Phenotyping and genotyping in normal healthy volunteers in western India. (Department of Biotechnology funded)

4. Studies with Liposomal Amphotericin B for expanding use optimising dose, duration, safety and efficacy and reduce cost in systemic fungal infection in India. (Department of Biotechnology funded)

5. Safety and Efficacy of Fugisome [Liposomal Amphotericin B] versus Conventional AmphotericinB in the empirical treatment of Febrile Neutropenia. (Department of Biotechnology funded)

6. Evaluation of the activity of Cytocrome P450 2C9 (CYP2C9) activity in normal healthy, Adult Maharashtrian ,Gujarati, and Marwadi subjects ( Western India) by phenotyping and genotyping. (Department of Biotechnology funded)

7. Evaluation of Cytochrome P450 2E1 (CYP2E1) activity in healthy, adult Maharashtrian subjects by phenotyping and genotyping. (Department of Biotechnology funded)